Predicting the effect of detected SNPs or indels.
SnpEff is a variant annotation and effect prediction tool. The Annotate VCF tool utilizes this program from Subio Platform's GUI. You have to use this tool before using aggregation tools. They say it accepts both .vcf and .vcf.gz files, but it may work fine only with .vcf files. So I recommend you uncompress the .gz files.
if you don't find a database which is suitable for your data, please build it by yourself.